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A network for internally directed thought
The default mode network links distributed brain territories involved in internally directed cognition.
CRH→Anterior pituitary
ACTH→Adrenal cortex
Cortisol
CRH: corticotropin-releasing hormone · ACTH: adrenocorticotropic hormone. Cortisol feeds back to regulate the axis. The adrenal cortex is outside this brain model.
Methods & sources
How to read the colours. Anatomy is shown in its deposited spatial relationships. Colour identifies selected anatomical territories. No colour represents measured activity, functional connectivity, receptor density or a treatment effect. Default-network boundaries vary across people and functional parcellations. The medial prefrontal highlight selects a medial/anterior portion of the superior frontal anatomy; the full default network extends beyond these four landmarks.
Default mode network. Andrews-Hanna et al. (2010), functional-anatomic fractionation; Carhart-Harris et al. (2012), psilocybin fMRI; Siegel et al. (2024), psilocybin and brain synchrony.
Amygdala. Tyszka & Pauli (2016), CIT168 subdivisions; Bickart et al. (2012), amygdala-cortical networks; Kraehenmann et al. (2015), acute emotion processing. Task responses, resting-state correlations and effective connectivity are distinct measures.
Stress and plasticity. Herman et al. (2016), HPA regulation; Hasler et al. (2004), acute psilocybin endocrinology; Shao et al. (2021), frontal dendritic spines in mice. A whole-brain surface model cannot show synapses or establish neurogenesis.
Anatomy and reuse. Reference geometry from Itay Inbar’s Brain Atlas, derived from Z-Anatomy / BodyParts3D © DBCLS and registered imaging atlases. Geometry and derived preview images/video: CC BY-SA 4.0. Amygdala groups: CIT168 (Tyszka & Pauli); hypothalamic zones: Neudorfer et al. Approximate atlas registration has ~7 mm held-out error; these views are educational and cannot resolve fine nuclei reliably.
Model provenance · Anatomy attribution and licences · Source registration method · Three.js licence · Draco licence