Psilocybin-Research.com Bibliometrics, context and science communication

Credits and acknowledgements

Data sources

  • Database. PubMed / NLM, Crossref, Europe PMC, OpenAlex / OurResearch (CC0 and terms), medRxiv, bioRxiv, PsyArXiv and ClinicalTrials.gov supply publication, preprint and clinical-trial registration metadata for the Psilocybin Research database.
  • Interactive brain anatomy. Brain networks, emotion and stress uses reference geometry from Itay Inbar’s Brain Atlas, derived from Z-Anatomy / BodyParts3D © DBCLS and registered imaging atlases. Anatomy and derived preview media are CC BY-SA 4.0. Amygdala subdivisions derive from CIT168 (Tyszka & Pauli); hypothalamic zones from Neudorfer et al. Network territories are illustrative anatomical selections, not measured functional maps. On hover, the preview arranges anatomical groups by projected size; leaving restores their source positions. This layout is illustrative, not anatomical motion or measured activity. Provenance · Attribution and licences. Draco geometry decoder © Google, Apache 2.0 · Licence.
  • Chromosome-end overview. The hero and interactive guide share the same chromosome geometry and depict a condensed, replicated chromosome: two sister chromatids, each with two ends, giving four highlighted telomere locations. An unreplicated chromosome has two ends. The hero’s illustrative striped surface relief is baked into the interactive model; it is not an experimental chromosome-banding pattern. These original schematics are not to scale; the enlarged gold tips indicate location, not telomere length or molecular structure.
  • Telomere and telomerase sequences. The human G-rich telomere strand is shown as 5′-(TTAGGG)n-3′; its antiparallel C-rich complement, written 5′ to 3′, is 5′-(CCCTAA)n-3′. Human telomerase synthesis of TTAGGG repeats was reported by Morin (1989). The modeled 11-nucleotide TERC template/alignment segment, 5′-CUAACCCUAAC-3′, is not copied end-to-end as one repeat.
  • 5-HT2A receptor and psilocin. Interactive receptor guide and matching rotation preview use PDB 9AS8 (2.54 Å cryo-EM), Gumpper et al., Nature Communications (2025). The protein cartoons and psilocin atoms follow the deposited coordinates; the pocket selection uses a 4.0 Å heavy-atom distance cutoff. Chain B is an engineered Gi2–mini-Gq construct; stabilising scFv16 chain E is omitted. Rotation is a change of viewpoint, not simulated receptor activation. Coordinate data: CC0. Structural provenance.
  • Experimental structures. PDB 2JSL (telomeric G-quadruplex DNA) and PDB 7BG9 (human telomerase catalytic core). The 7BG9 model includes an 18-nucleotide synthetic DNA substrate, 5′-TTTTTTTTTTTTTTAGGG-3′; it is distinct from the canonical telomeric repeat tract. Ghanim et al. (2021).

Journal references

  1. de Lange T (2018). Shelterin-Mediated Telomere Protection. Annual Review of Genetics, 52, 223-247. doi:10.1146/annurev-genet-032918-021921
  2. Phan AT, Kuryavyi V, Luu KN, Patel DJ (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Research, 35(19), 6517-6525. doi:10.1093/nar/gkm706
  3. Morin GB (1989). The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell, 59(3), 521-529. doi:10.1016/0092-8674(89)90035-4
  4. Ghanim GE, Fountain AJ, van Roon AM, Rangan R, Das R, Collins K, Nguyen THD (2021). Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593(7859), 449-453. doi:10.1038/s41586-021-03415-4
  5. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL (2010). Functional-anatomic fractionation of the brain's default network. Neuron, 65(4), 550-562. doi:10.1016/j.neuron.2010.02.005
  6. Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences of the United States of America, 109(6), 2138-2143. doi:10.1073/pnas.1119598109
  7. Siegel JS, Subramanian S, Perry D, Kay BP, Gordon EM, Laumann TO, Reneau TR, Metcalf NV, Chacko RV, Gratton C, Horan C, Krimmel SR, Shimony JS, Schweiger JA, Wong DF, Bender DA, Scheidter KM, Whiting FI, Padawer-Curry JA, Shinohara RT, Chen Y, Moser J, Yacoub E, Nelson SM, Vizioli L, Fair DA, Lenze EJ, Carhart-Harris R, Raison CL, Raichle ME, Snyder AZ, Nicol GE, Dosenbach NUF (2024). Psilocybin desynchronizes the human brain. Nature, 632(8023), 131-138. doi:10.1038/s41586-024-07624-5
  8. Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC (2021). Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron, 109(16), 2535-2544.e4. doi:10.1016/j.neuron.2021.06.008
  9. Gumpper RH, Jain MK, Kim K, Sun R, Sun N, Xu Z, DiBerto JF, Krumm BE, Kapolka NJ, Kaniskan HÜ, Nichols DE, Jin J, Fay JF, Roth BL (2025). The structural diversity of psychedelic drug actions revealed. Nature Communications, 16(1), 2734. doi:10.1038/s41467-025-57956-7
  10. Xu Z, Wang H, Yu J, Deng Y, Tian X, Ni R, Xia F, Yang L, Xu C, Zhang L, Luo R, Chen P, Zhang X, Liu Y, Hou J, Zhang M, Chen S, Su L, Sun H, He Y, Chen D, Chen X, Miao Z, Xie J, Liu X, Zhao J, Ke B, Tian X, Zeng L, Zhang L, Tang X, Yang S, Liu J, Wang X, Yan W, Shao Z (2026). Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling. Nature, 651(8106), 829-837. doi:10.1038/s41586-025-10061-7
  11. Tyszka JM, Pauli WM (2016). In vivo delineation of subdivisions of the human amygdaloid complex in a high-resolution group template. Human Brain Mapping, 37(11), 3979-3998. doi:10.1002/hbm.23289
  12. Bickart KC, Hollenbeck MC, Barrett LF, Dickerson BC (2012). Intrinsic amygdala-cortical functional connectivity predicts social network size in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(42), 14729-14741. doi:10.1523/jneurosci.1599-12.2012
  13. Kraehenmann R, Preller KH, Scheidegger M, Pokorny T, Bosch OG, Seifritz E, Vollenweider FX (2015). Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers. Biological Psychiatry, 78(8), 572-581. doi:10.1016/j.biopsych.2014.04.010
  14. Herman JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B (2016). Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Comprehensive Physiology, 6(2), 603-621. doi:10.1002/cphy.c150015
  15. Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX (2004). Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study. Psychopharmacology, 172(2), 145-156. doi:10.1007/s00213-003-1640-6
  16. Neudorfer C, Germann J, Elias GJB, Gramer R, Boutet A, Lozano AM (2020). A high-resolution in vivo magnetic resonance imaging atlas of the human hypothalamic region. Scientific Data, 7(1), 305. doi:10.1038/s41597-020-00644-6
  17. Pauli WM, Nili AN, Tyszka JM (2018). A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei. Scientific Data, 5, 180063. doi:10.1038/sdata.2018.63
  18. Najdenovska E, Alemán-Gómez Y, Battistella G, Descoteaux M, Hagmann P, Jacquemont S, Maeder P, Thiran JP, Fornari E, Bach Cuadra M (2018). In-vivo probabilistic atlas of human thalamic nuclei based on diffusion- weighted magnetic resonance imaging. Scientific Data, 5, 180270. doi:10.1038/sdata.2018.270

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DeepDive podcast. RevGenetics · Original source · Channel.

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Corrections: christopher-germann@uni-wh.de · Editorial policy.